Guerra Plastic Surgery Center
Call us at (480) 970-2580

Restylane® Refyne and Defyne

New smooth treatment for laugh lines.

Restylane® Refyne & Restylane® Defyne

The face is typically the first place we notice aging. Laugh lines, or lines from the nose to the corners of the mouth (nasolabial folds), may deepen. The marionette lines, or the lines from the corners of the mouth that run toward the bottom of the chin, may become more noticeable. The skin around the mouth may not look and feel as smooth and firm as it once did and show fine wrinkles (crepey skin).

Fortunately, there are treatment options to help reduce the signs of aging to the laugh lines and temporarily restore a more youthful appearance all while being able to maintain your normal facial expressions. Consider the hyaluronic acid fillers Restylane® Refyne or Restylane® Defyne. These new dermal fillers have been designed to create way more natural looking results than previous fillers.

What is Hyaluronic Acid?

Hyaluronic acid (HA) is a naturally occurring substance in the human body. It is a sugar-based compound that helps deliver and maintain moisture and nutrient levels in the cells. It is found in soft connective tissue, the fluid around our eyes, in some cartilage and joint fluids, as well as our skin. Hyaluronic acid helps create volume, smoothness and elasticity to the skin. As we age, the hyaluronic acid in our bodies diminishes, resulting in loss of volume and increased aging. This volume loss leads to the appearance of wrinkles, folds and depressions in the skin.

Kristen before Restylane Defyne Kristen after Restylane Defyne
Kristen, before and after 2 weeks of Restylane® Defyne.
Images courtesy of Galderma Laboratories, L.P. used by their permission.

What Makes Restylane® Refyne & Restylane® Defyne Different From Other HA Fillers?

Today, the most popular dermal fillers contain hyaluronic acid. When injected, the hyaluronic acid helps to bolster fullness and volume. You may recognize these fillers by brand name, like the Restylane® family fillers such as Restylane-L®, Restylane® Lyft and Restylane® Silk, or Juvederm® family fillers such as Juvederm® Ultra, Volbella, Voluma and Vollure. These fillers all contain hyaluronic acid. What makes them different are slight differences in the formulation and the size of the particles. For instance, Restylane® Silk tends to have very fine particles (great for crepey skin) compared to Restylane® Lyft that has larger particles (great for lifting tissue). This would be like comparing fine sugar granules to raw sugar-the raw sugar particles being much bigger. Restylane® Silk’s fine particles are suited for injecting into the lips, for a smooth, natural appearance. Restylane® Lyft is better suited for bringing more volume to the cheek area.

Restylane® Refyne & Restylane® Defyne are next generation fillers that incorporate XpresHAn Technology™. As we discussed particle size earlier, Restylane® Refyne and Restylane® Defyne would be similar to honey on the particle spectrum from raw sugar to refined sugar. This means that when injected, it feels smooth, and as you make facial expressions, the product moves with you. With older HA fillers, patients sometimes complain that when they make facial expressions like smiling, they are able to see evidence of fullness where the filler was placed. With Restylane® Refyne and Defyne, which is the latest innovation in dermal fillers, the product has fluidity. This means the filler will keep you looking like you and flexes and moves with your facial expressions to give you a natural, never stiff look.

Elfie before Restylane Refyne Elfie after Restylane Refyne
Elfie, before and after 2 weeks of Restylane® Refyne.
Images courtesy of Galderma Laboratories, L.P. used by their permission.

What is Best for Me? Restylane® Refyne or Restylane® Defyne?

The depth of the wrinkles or folds will determine which of these cutting edge fillers is appropriate to use. Restylane® Refyne is typically used to treat small to moderate wrinkles and folds. Restylane® Defyne is used to treat moderate to severe deep wrinkles and folds. Our experienced injectors will discuss your concerns and evaluate you to determine which of these products would give you the optimal natural-looking result.

Are There Any Reasons I Should NOT Get Restylane® Refyne or Restylane® Defyne?

Our primary concern is your safety. At each visit, we take a medical history to determine if these products are safe and appropriate for you. You should not use these products if:

  • You have severe allergies with a history of severe reactions (anaphylaxis).
  • You are allergic to lidocaine or to any of the proteins used to make hyaluronic acid.
  • You are prone to bleeding or have been diagnosed with a bleeding disorder.
  • You are breastfeeding, pregnant, or trying to become pregnant. The safety of these products for use during pregnancy, or in women who are breastfeeding, has not been studied.
  • You have any history of scarring, particularly thick and stiff scars, or any pigmentation (skin color) disorders. These side effects can occur with hyaluronic acid fillers in general.

What Are Some of The Side Effects?

The most commonly observed side effects are typically mild in severity and usually resolve in 7-14 days. The most commonly observed side effects include:

  • swelling
  • redness
  • pain
  • headache
  • tenderness
  • lump formation
  • itching at the injection site

Serious but rare side effects include delayed onset infections, recurrence of herpetic eruptions, and superficial necrosis at the injection site. One of the risks with using this product is unintentional injection into a blood vessel. The chances of this happening are very small, but if it does happen, the complications can be serious, and may be permanent. These complications, which have been reported for facial injections, can include vision abnormalities, blindness, stroke, temporary scabs, or permanent scarring of the skin. While the satisfaction rate is extremely high with these new dermal fillers, not everyone likes the way they look after injections. In such cases, we offer the opportunity for each patient to have the filler completely dissolved in office.

How Long Does Restylane® Refyne and Restylane® Defyne Last?

Results from Restylane® Refyne or Restylane® Defyne may last up to one year post treatment.

If you are looking for a dermal filler that will help you look more youthful, natural-looking appearance, while helping you maintain your natural expressions, consider Restylane® Refyne or Restylane® Defyne.

Sign up for the Galderma Aspire Rewards Program

Restylane® Refyne / Defyne

Schedule an Appointment
Menu of Non-Surgical Services
miraDry® $2450 $1700
Dysport® $4 / Unit
BOTOX® Cosmetic $12 / Unit
Restylane®-L $525 / mL
Restylane® Silk $575 / mL
Restylane® Lyft $600 / mL
Restylane® Refyne $625 / mL
Restylane® Defyne $625 / mL
Juvéderm® Ultra XC $675 / mL
Juvéderm® Voluma XC $850 / mL
Juvéderm® Vollure XC $775 / mL
Juvéderm® Volbella XC $475 / 0.5 mL
Sculptra® $800 / Unit
KYBELLA® $600 / Vial

* Cannot be combined with other promotions.

Aldo Guerra, MD, FACS

Aldo Guerra, MD, FACS

Dr. Aldo Guerra trained specifically and extensively for a career in cosmetic plastic surgery. After completing his plastic surgery training he passed the qualifying examination to become board certified in plastic surgery by The American Board of Plastic Surgery. He has over 15 years of experience practicing plastic surgery.

Schedule an Appointment

Gail Gomez, RN, BSN

Gail Gomez, RN, BSN

Gail Gomez is an Advanced Cosmetic Injector specializing in non-surgical treatments to restore and enhance one's natural beauty. She has a Bachelor of Science degree in Nursing, and worked in aesthetic medicine since 2007.

Schedule an Appointment